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Effect of partial obstruction on the contraction of guinea pig jejunum
Author(s) -
Zhao Jingbo,
Liao Donghua,
Yang Jian,
Gregersen Hans
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1326-b
Subject(s) - distension , jejunum , contraction (grammar) , lumen (anatomy) , medicine , guinea pig , anatomy , cardiology , chemistry
The hypertrophied intestine proximal to an obstruction show abnormal motor function. We compared flow and inflation‐induced contractions in the normal, sham‐obstructed and partial obstructed guinea pig jejunum. The obstruction was created in animals living for 2, 4, 7 and 14 days with six animals in each group. Six cm jejunal segments proximal to the intervention site were immersed in an organ bath containing 37 °C aerated Krebs solutions at pH 7.4. The intestinal lumen was perfused at 0.8 ml/min. Then, the outlet was closed and ramp distension of 0–7.5 cmH 2 O was done. The pressure and outer diameter were recorded. Data are shown in Table. In conclusion, partial obstruction time‐dependently decreased frequency and amplitude of flow‐induced contractions, and increased pressure threshold and maximal amplitude of inflation‐induced contractions. The study was supported by Aalborg Hospital.