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Physiological and histopathological changes of rabbit liver and kidney exposed to agricultural drainage water
Author(s) -
Okab Aly Bassunny,
Elbanna Sabah Gaber,
Yehia Mona A,
Koriem Ahmed A
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1324-d
Subject(s) - creatinine , alkaline phosphatase , kidney , lactate dehydrogenase , medicine , blood urea nitrogen , urea , zoology , chemistry , biology , biochemistry , enzyme
Twenty‐four mature male New‐Zealand white rabbits were used to study the possible adverse effects of drinking agricultural drainage water on liver and kidney functions. The bucks were randomly distributed to three groups, the animals of the first group (G1) were offered tap water (TW) and served as control, the second group (G2) drank 100% drainage water (DW), while the third group (G3) drank mixed water (50% TW:50% DW). The treatment period extended for 4 months, followed by 2 months as a recovery period where the bucks drank TW. Blood samples were obtained from each animal every two weeks via the ear vein. Aspartate amino transferase (AST), AST/ALT ratio, lactate dehydrogenase (LDH), and creatinine were increased in G2 and G3 during the treatment period. Alkaline phosphatase (ALP) and urea/creatinine ratio were decreased in G2 and G3 during the treatment period. During the recovery period, creatinine was increased, while, ALP and urea/creatinine ratio were decreased. Histopathological changes of liver and kidney were observed in animals that drank agricultural drainage water. Histochemical LDH activity revealed an increase in both liver and kidney tissues in G2 and G3 groups. However, the ALP was increased in liver tissues and decreased in kidney tubules. In concluded drinking agricultural drainage water have a bad effects on liver and kidney functions that may last during the recovery period.