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Cutaneous Vasodilation and Sweating In Grafted Skin During Heat Stress 5–9 Months Post‐Surgery: A 1‐Year Follow‐up
Author(s) -
Davis Scott L,
Shibasaki Manabu,
Cui Jian,
Low David A,
Keller David M,
Wingo Jonathan E,
Kimura Kenichi,
Purdue Gary F,
Kowalske Karen J,
Crandall Craig G
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1312-b
Subject(s) - vasodilation , medicine , thermoregulation , skin temperature , sweat , anesthesia , hyperthermia , heat stress , surgery , skin reaction , dermatology , zoology , biology
The aim of this investigation was to examine the effect of 1‐year of healing on cutaneous vasodilation and sweat rate (SR) during indirect whole body heating (WBH) in split‐thickness grafted skin initially tested 5–9 months post‐graft surgery. Skin blood flow and SR were assessed from grafted skin and adjacent healthy control skin during normothermia (NT) and WBH (increased internal temperature ~0.8 °C via water‐perfused suit) in subjects 5–9 months post‐surgery (n=7) and again 1‐year following the initial evaluation. In the follow‐up evaluation, cutaneous vasodilation of grafted skin during WBH (Δ14.6±4.4%CVC max from baseline) was not different from data obtained 5–9 months post‐surgery (Δ8.6±7.0 %CVC max ; P=0.91), while ΔSR was significantly higher (0.08±0.08 mg/cm 2 /min) compared to 5–9 months post‐surgery (0.01±0.01 mg/cm 2 /min; P=0.002). Cutaneous vasodilator and SR responses at both time points were significantly lower compared to adjacent control skin. Small, but significant, increases in SR in the follow‐up evaluation suggest thermoregulatory responses in grafted skin may show some improvement over time. Despite these improvements, cutaneous vasodilation and SR remained attenuated, relative to control, in grafted skin during WBH. Thus, the ability of grafted skin to contribute to thermoregulation remains attenuated up to 21 months following surgery. Project funded by NIH GM68865 & GM71092