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Role of nitric oxide in active cutaneous vasodilation in individuals with type 2 diabetes mellitus
Author(s) -
Sokolnicki Lynn Ann,
Roberts Shelly,
Basu Ananda,
Charkoudian Nisha
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1311-b
Individuals with type 2 diabetes mellitus (T2DM) may exhibit impaired thermoregulation, but the mechanism(s) remain unclear. Our goal was to assess the contribution of nitric oxide (NO) to active cutaneous vasodilation during whole body heating (WBH) in individuals with T2DM compared to age‐matched controls. We measured skin blood flow (laser‐doppler) during intradermal microdialysis of L‐NAME (NO synthase inhibitor) or vehicle, during WBH in 5 individuals with T2DM and 7 controls. Baseline cutaneous vascular conductance (CVC) was higher in T2DM subjects at vehicle sites (19 ± 2 vs 12 ± 2 %maxCVC; P < 0.05) but not at L‐NAME sites (9 ± 1 vs 10 ± 1 %maxCVC; P > 0.10). After increasing internal temperature by 1°C, CVC values were similar between groups at both sites (T2DM: vehicle 58 ± 6, L‐NAME 28 ± 6 %maxCVC; control: vehicle 56 ± 5, L‐NAME 30 ± 4 %maxCVC; P > 0.10). The calculated contribution of NO to the vasodilator response was not different between groups (T2DM: 30 ± 5%, control: 26 ± 3%; P > 0.05). We conclude that the relative contribution of NO to active cutaneous vasodilation is not different between relatively healthy individuals with T2DM and controls. Supported by NIH HL73884