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The Effects of Liposomal‐ATP on Intracellular ATP of Hypoxic Dermal Fribroblasts
Author(s) -
Thomas Candice Michelle,
Caple Cathie,
Ehringer William
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1285-c
Subject(s) - wound healing , granulation tissue , intracellular , medicine , pharmacology , surgery , chemistry , biochemistry
In chronic wounds such as diabetic foot ulcers and pressure sores, ATP/energy is the rate‐limiting is the wound healing process. Large wounds require an increased metabolic demand in order to produce the necessary factors for wound closure. However, the ischemia that accompanies these wounds compromises the oxygen supply/energy needed to maintain viability of the wound border cells. As a result, the healing process is delayed and impaired. Our previous wound healing study showed that liposomal‐ATP can increase wound closure rates and granulation tissue deposition. In this study, we are investigating the use of liposomal‐ATP to restore intracellular ATP to normal levels in hypoxic dermal fiborblasts.