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Reduced Blood Flow in Carotid Arteries is a Trigger Contributing to Peripheral Chemoreflex Hypersensitivity in Chronic Heart Failure Rabbits
Author(s) -
Ding Yanfeng,
Li Yulong,
Cornish Kurtis G,
Schultz Harold D
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1268-c
Subject(s) - peripheral , medicine , heart failure , blood flow , cardiology , hypoxia (environmental) , carotid body , common carotid artery , endocrinology , carotid arteries , chemistry , organic chemistry , oxygen
Peripheral chemoreflex sensitivity is potentiated in both clinical and experimental chronic heart failure (CHF). Blood supply to tissues is inevitably reduced in CHF. However, it remains poorly understood whether the reduced blood flow is the trigger to increase peripheral chemoreflex sensitivity in CHF. This work highlights the effect of the reduced blood flow to the carotid body (CB) on peripheral chemoreflex function in rabbits. In the Pacing‐induced CHF model in rabbits, blood flow in the carotid artery was reduced by 32.4±5.2% (from baseline 74.8±9.4 to 51.0±6.7 ml/min, P<0.05) after 3 weeks of pacing. The same level of blood flow reduction induced by occluders on both carotid arteries over a similar time course (3 weeks) enhanced peripheral chemoreflex sensitivity in response to the hypoxia compared with sham rabbits, to a level similar to that has been observed in CHF rabbits. Immunofluorescent staining and western blotting showed that protein expression of AT1 receptors in CB was higher and nNOS expression was lower than those from sham rabbits respectively, These changes were similar to those seen in the CB from CHF rabbits. These results suggest that a reduction of blood flow to the CB is involved in the augmentation of peripheral chemoreflex sensitivity in CHF.