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A Possible Role for B type Natriuretic Peptide (BNP) in Modulating Absorption from the Gastrointestinal Tract
Author(s) -
Addisu Anteneh,
Gower William R.,
Landon Carol S.,
Dietz John R.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1259-a
Subject(s) - natriuretic peptide , natriuresis , gastrointestinal tract , medicine , heart failure , diuresis , brain natriuretic peptide , myocardial infarction , endocrinology , vasodilation , absorption (acoustics) , cardiology , kidney , acoustics , physics
BNP is released from cardiac myocytes after acute myocardial infarction (MI) or/and during heart failure. While the role of BNP in promoting diuresis, natriuresis and vasodilatation is well established, its potential role in modulating input through the gastrointestinal (GI) tract has yet to be defined. Our prior studies have shown that BNP decreases intragastric pressure. The purpose of this study was to determine if BNP has an effect on absorption in the GI tract. Conscious C57BL/6 (WT) & Natriuretic Peptide Receptor A (NPR‐A) knock out (KO) mice were given 10ng/g of BNP i.v. dissolved in 100μl of modified Krebs or the vehicle alone (Control). This BNP dose was calculated to raise the plasma BNP to 500pg/ml which is consistent with a 90% likelihood of heart failure in humans. The mice were then gavaged with 0.01ml/g of a solution containing 22mg/ml of 4KD FITC‐dextran. The plasma fluorescence measured 1 hour after gavage in WT mice was 23.3 ± 7.8 for BNP treated vs. 104.7 ± 32 for control (P<0.05). For KO mice it was 64.3 ± 19.3 in BNP treated vs. 95.1 ± 70 for control (P>0.05). The results show that BNP affects absorption in the GI tract and this effect appears to be mediated by NPR‐A. We postulate that this effect of BNP could be aimed at modulating absorption from the GI tract in states such as heart failure where maintaining volume status is critical for survival. (Support: V. A. Merit Award to WR Gower, Jr. and NSF IGERT grant 0221681)