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Towards automating the pulmonary artery catheter: a canine validation study
Author(s) -
Mukkamala Ramakrishna,
Xu Da,
Padhi Kabi,
Olivier Nicholas Bari
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1257-b
Subject(s) - waveform , medicine , catheter , pulmonary artery , calibration , cardiac output , cardiology , pulmonary artery catheter , biomedical engineering , diastole , hemodynamics , surgery , mathematics , computer science , blood pressure , statistics , telecommunications , radar
We aimed to develop and conduct animal testing of a unique technique for continuous and automatic monitoring of both cardiac output (CO) and left atrial pressure (LAP) by mathematical analysis of a pulmonary artery pressure (PAP) waveform. Our technique specifically analyzes the PAP waveform over long time scales in which the confounding wave and inertial effects are attenuated so as to simultaneously estimate average proportional CO and absolute LAP based on a lumped parameter model. The proportional CO estimates may then be conveniently calibrated with a single thermodilution measurement. To evaluate the technique, we performed an experiment in a closed‐chest dog in which the PAP waveform and highly invasive, gold standard aortic flow probe CO and LAP catheter measurements were simultaneously recorded during various pharmacological interventions. We report that the technique achieved an overall CO error of 15.1% after a single calibration and an overall LAP error of 14.4%. For comparison, the LAP error via conventional end‐diastolic PAP estimates was over twice as high. With further successful testing, the technique may ultimately be employed so as to effectively automate the pulmonary artery catheter. This work was supported by the NHLBI Grant HL‐080568 and an award from the American Heart Association.