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T. violacea lowers blood pressure and down regulates AT1a gene expression in a hypertensive rat model
Author(s) -
Mackraj Irene,
Ramesar Shamal,
Singh Ravesh
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1247-b
Subject(s) - captopril , renin–angiotensin system , endocrinology , blood pressure , excretion , medicine , chemistry , sodium , aldosterone , kidney , messenger rna , urine , angiotensin ii , biology , biochemistry , gene , organic chemistry
The in vivo effects of Tulbagia violacea, also known as wild garlic, in a salt‐sensitive rat model and its effects on AT1a receptor mRNA expression in kidney tissues was investigated. Three month old Dahl salt‐sensitive received, daily, for 14 days T. violacea 50mg/kg (TvL); captopril 10 mg/kg b.w. (Cap) or DMSO (Con). Blood pressures were monitored prior to the commencement of the study and biweekly and urine volume and sodium concentration was measured on days 0, 7 and 14. On day 15, animals were anaesthetized (sodium thiopentane, 50 mg/kg), blood samples for aldosterone levels were taken and kidneys removed for AT1a mRNA expression. Tvl and Cap groups showed reduced AT1a mRNA expressions respectively when compared to the control group. Decreases in systolic blood pressures mirrored decreases in AT1a mRNA expressions in all groups. Tvl and Cap showed reductions in SBP of 10.8% and 11% respectively from day 0 to day 14. Urine output in the Cap and Tvl groups increased and sodium excretion increased from Day 0 to 14. The actions of captopril and TVL on blood pressure, urinary volume and sodium excretion may be attributed to an interruption of the renin‐angiotensin pathway.