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Free fatty acids in insulin‐resistant individuals are associated with the insulin‐resistant state but not with central obesity
Author(s) -
Ryder Elena,
Campos Gilberto,
Fernandez Virginia,
Fernandez Erika,
Molero Emperatriz,
Morales Luz Marina,
Raleigh Xiomara,
Connell Lissette
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1198-c
Subject(s) - medicine , insulin resistance , endocrinology , basal (medicine) , insulin , obesity , carbohydrate metabolism , waist , chemistry , lipid metabolism , carbohydrate , metabolism , biology
There is growing evidence that an increase in free fatty acids (FFAs) levels plays an important role in insulin resistant obese individuals. The objective of this study was to analyze the relationship between changes in FFAs levels in individuals with (n=18) or without insulin resistance (IR) (n=29), and the presence of central obesity and parameters from carbohydrate and lipid metabolism. Concentrations of TG, LDLc, VLDLc, and HDLc were measured in the basal state and FFAs, glucose and insulin levels were determined at time 0, 60 and 120 min after a glucose load. The results show that individuals with IR (HOMA‐IR >2.7) had higher waist circumference (108 ± 15 cm vs 98 ± 12 cm; p<0.01) and BMI (34.5 ± 7.0 vs 29.2 ±5.3; p<0.005) as well as higher basal concentrations of FFAs (0.50 ± 0.14 mmol/L vs 0.42 ± 0.11 mmol/L; p<0.05) in comparison with those without IR (HOMA‐IR ≤2.7). No differences were observed in other basal lipid levels. After the glucose load, the patterns of the decrease in FFAs were similar in both groups, however in those with IR the FFAs levels remained significantly elevated at 60 (p< 0.01) and 120 min (p<0.002). We found that concentrations of FFAs were associated with the HOMA‐IR (r = 0.679, p<0.002) and with glucose (r = 0.749, p<0.003) and TG (r = 0.52, p<0.02) levels; however, there was no association with parameters related to central obesity as BMI or waist circumference. Financed by CDCHT‐LUZ