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Myeloperoxidase is Elevated in the Circulation of Obese Women with Preeclampsia
Author(s) -
Gandley Robin E.,
Rohland Jennifer R.,
Rajakumar Augustine,
Hubel Carl A.,
Powers Robert W.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1194
Subject(s) - preeclampsia , myeloperoxidase , medicine , endothelial dysfunction , endocrinology , oxidative stress , pregnancy , obesity , gestation , inflammation , biology , genetics
OBJECTIVE: To determine if patients with preeclampsia (PE), a hypertensive pregnancy disorder associated with inflammation, endothelial dysfunction, and oxidative stress, have higher plasma levels of myeloperoxidase (MPO) compared to patients with normal pregnancies (NP) and if this difference is accentuated by pre‐pregnancy obesity (BMI>30), a known risk factor for preeclampsia. METHODS: EDTA‐ plasma samples were obtained during the third trimester from non‐obese (BMI<30) PE (n=11, BMI 25±1) and non‐obese NP (n=17, BMI 23±8), and from obese PE (n=14, BMI 35±4) and obese NP (n=14, BMI 35±1) patients. MPO concentrations were measured by EIA. RESULTS: Plasma MPO levels were significantly elevated in non‐obese patients with PE compared to non‐obese NP (23.6± 12 vs. 2.0± 0.8 ng/mL p<0.05). In obese patients, MPO concentrations were further elevated in PE compared to NP (90±9 vs. 64 ± 8 ng/mL, respectively). MPO plasma levels did not change significantly between mid‐gestation and delivery in uncomplicated pregnancies. CONCLUSION: Elevated MPO in the circulation of women with preeclampsia may contribute to the oxidative damage reported in the vasculature. Supported by NIH grant HD30367.