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Vascular heme oxygenase‐1 expression is correlated with levels of LDL in atherosclerotic patients
Author(s) -
Tejerina Teresa,
Ruiz Emilio,
Redondo Santiago,
GordilloMoscoso Antonio
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1172-b
Subject(s) - heme oxygenase , heme , medicine , biliverdin , body mass index , coronary arteries , cardiology , artery , endocrinology , gastroenterology , pathology , enzyme , biochemistry , chemistry
Background: Heme oxygenase‐1 (HO‐1) is an inducible enzyme that catalyzes the degradation of heme group into iron, carbon monoxide and biliverdin. The expression of HO‐1 is induced by oxidants such as oxidized low density lipoproteins (oxLDL). Aim: The aim of this study was to study, firstly, the expression of HO‐1 in arteries from atherosclerotic patients who underwent coronary‐artery bypass graft (CABG) and then to evaluate which serum parameters were related with this expression. Methods: Through a cross‐sectional design, atherosclerotic patients who underwent CABG were recruited. Biochemical and clinical data were collected from the medical record and by blood testing. HO‐1 expression was analyzed by confocal microscopy in cross‐sections of internal mammary arteries. Results: HO‐1 was expressed in arteries from atherosclerotic patients, in the same extent in hypertensives, hyperlipidemics and diabetics. The bivariate analysis of the variables showed that HO‐1 expression was not related with the gender, age, body mass index, triglycerides or glucose levels. However, HO‐1 expression was positively related with the serum levels of LDL (r2=0.582, P=0.006). Conclusions: Although in vitro studies have revealed that HO‐1 expression was induced by oxLDL, to our knowledge, this is the first time that vascular HO‐1 expression in atherosclerotic patients is related with the levels of LDL. This work was funded by Fondo de Investigaciones Sanitarias FISS 01/0815 (Health Research Fund from the Spanish Ministry of Health) and by RECAVA. We thank to the Cardiac Surgery Service, (Hospital Clínico San Carlos, Madrid) for providing us the internal mammary arteries.