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Increased ICP or Subarachnoid Blood Responsible for CBF Reduction and Receptor Upregulation after SAH
Author(s) -
Beg Saema,
Edvinsson Lars
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1168-a
Subject(s) - medicine , vasoconstriction , subarachnoid hemorrhage , intracranial pressure , cerebral blood flow , ischemia , anesthesia , saline , blood pressure , endothelin receptor , cardiology , receptor
Objective: Cerebral ischemia remains the key cause for disability and death in patients who have suffered subarachnoid hemorrhage (SAH). The purpose of the present study was to examine whether the change in intracranial pressure (ICP) or the extravasated blood causes the cerebral ischemia and cerebral vasoconstriction observed following SAH. Methods: Three groups of animals were studied; cisternal injection of 250 ul blood (SAH), cisternal injection of 250 ul NaCl (saline) or same procedure in every detail but no fluid injection (sham). Two days after the SAH the cerebral arteries were harvested and contractile responses to endothelin‐1 (ET‐1) and 5‐carboxamidotryptamine (5‐CT) were investigated in myographs To investigate if the ICP or injected blood had an influence on the regional and global CBF after SAH an autoradiographic CBF technique was used. Results: Both SAH (blood + ICP) and saline injection (ICP only) resulted in significantly enhanced contractions to ET‐1 and 5‐CT, as compared to sham in cerebral arteries. Regional and global CBF were reduced both in saline and SAH operated rats as compared to sham. Conclusion: This study revealed that both the elevation of ICP and blood per se contributed approximately equally to the SAH induced effects. The study was supported by the Swedish Heart‐Lung Foundation and the Lundbeck Foundation.