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Defining a role for LYRIC in NF‐kappaB signaling and prostate tumor progression
Author(s) -
Britt Deborah E.,
Ash Steven,
Yang DongQin
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1151
Subject(s) - prostate cancer , gene knockdown , cancer research , tumor progression , prostate , signal transduction , biology , medicine , gene , cancer , microbiology and biotechnology , genetics
LYRIC (AEG‐1/metadherin) is a highly conserved protein that we have previously shown to be localized to tight junctions in normal prostate, liver and other tissues. Data from our own lab and others suggest that LYRIC localization is altered in tumors, that LYRIC is capable of nuclear translocation, and that overexpression contributes to tumor progression. A recent paper by Emdad et al ., (2006 Cancer Res. 66:) also implicates LYRIC/AEG‐1 as an inducer of NF‐kappaB signaling. We have determined that LYRIC interacts with a nuclear protein, BCCIP/TOK‐1, that has been previously shown to associate with p21 (Cip1/Waf1) and enhance p21‐mediated cell cycle arrest. Using siRNA knockdown of LYRIC in human prostate tumor cell lines, we have observed altered expression of several potentially interesting genes, including p21. Efforts are ongoing to characterize the functional consequences of LYRIC/BCCIP interaction, and determine whether LYRIC modulates gene expression in human prostate tumor cells, potentially through a role in NF‐kappaB signaling. Supported by an allocation from NCRR 1 P20 RR17695‐01.