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Platelet Function and Coagulation During and Following Heat Stress
Author(s) -
Smith Denise L,
Busineau Pamela,
Miller Andrew,
Newell Scott,
Elphick Gwen
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1127-b
Subject(s) - platelet , partial thromboplastin time , fibrinogen , heat stress , prothrombin time , medicine , coagulation , cardiology , zoology , biology
Purpose: This study examined platelet function and coagulation during and following heat stress that was induced passively and in conjunction with exercise. Methods: Eight healthy, males (M = 20.4 yrs, Wt = 76.6 kg, VO2peak = 48 ml·kg·min‐1) participated in two heat stress conditions; exercise‐induced heat stress (EIHS) and passive heat stress (PHS). The EIHS condition consisted of 45 minutes of cycling while wearing encapsulating clothing. The PHS condition required subjects to sit in a tub of warm water for 45 minutes. Blood samples were collected pre, post, and 1‐hr post each condition and analyzed for platelet function, fibrinogen, prothrombin (PT), partial thromboplastin time (PTT), and complete blood count (CBC). A 2x3 RM ANOVA was run to determine significant effects for blood samples. Results: Tc increased significantly over time in both conditions, but there was no main condition effect. HR and TS increased significantly over time in both conditions, and HR and TS were higher during exercise. There was a significant main effect for time for platelet number, platelet function, fibrinogen, and PTT. There was a significant condition effect for PTT, WBC, and RBC, and a strong trend for platelets to be higher in the exercise condition (p=.06). Conclusion: The data suggest that heat stress, whether induced by exercise or passive heating, causes changes in platelet function and coagulatory potential.