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Hepatoprotective effect of dandelion(Taraxacum officinale) against acute liver injury induced by Carbon tetrachloride in Sprague‐Dawley rats
Author(s) -
Park Chungmu,
Zhou Yusi,
Song Youngsun
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1122-d
Subject(s) - carbon tetrachloride , dandelion , taraxacum officinale , liver injury , glutathione , ccl4 , chemistry , glutathione peroxidase , superoxide dismutase , distilled water , cyp2e1 , alanine aminotransferase , glutathione reductase , biochemistry , medicine , pharmacology , antioxidant , cytochrome p450 , enzyme , pathology , chromatography , organic chemistry , alternative medicine , traditional chinese medicine
The present study is to investigate the protective effect of dandelion hot water extract (DWE) on liver injury induced by carbon tetrachloride (CCl 4 ) in Sprague‐Dawley rats. Dandelion samples were extracted by hot water and lyophilized. The freeze‐dried DWE was dissolved in third distilled water and administered to rats by gavage at 500mg/kg, 2g/kg respectively for 7 consecutive days. The acute liver injury was induced by carbon tetrachloride (500ul/kg. p.o.) on the eighth day and 24 hours later all rats are sacrificed. The DWE supplement significantly decreased the serum alanine and aspartate aminotransferase (ALT and AST) activity. Comparing with the CCl 4 intoxicated group, the contents of glutathione peroxidase, glutathione reductase and superoxide dismutase increased dose, dependent manner, and mRNA and protein expression levels of cytochrome p450 2E1 significantly decreased in the dandelion administered group. These results indicate that DWE has protective effect on acute liver inflammation induced by CCl 4 in rats.