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Anti‐oxidative, anti‐inflammatory and anti‐atherogenic effects of Dandelion (Taraxacum officinale) extracts in C57BL/6 mice fed atherogenic diet
Author(s) -
Kim Jinju,
Noh Kyunghee,
Cho Mikyung,
Jang Jihyun,
Song Youngsun
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1122-c
Subject(s) - taraxacum officinale , triglyceride , dandelion , oxidative stress , superoxide dismutase , chemistry , catalase , lipid peroxidation , cholesterol , lipid profile , antioxidant , high cholesterol , glutathione peroxidase , polygonum , medicine , food science , traditional medicine , biochemistry , traditional chinese medicine , alternative medicine , pathology
Taraxacum officinale (TO), a tranditional oriental medicine, has been used for treatment of various inflammatory disorders in Korea. The study was conducted to investigate the effects of Taraxacum officinale extracts on oxidative stress, inflammation, and lipid profile in C57BL/6 mice fed atherogenic diet. Five groups of C57BL/6 mice were given atherogenic diet (control) and containing 1.5%, 3% Taraxacum officinale water extract (TOWE) and alcohol extract (TOAE) for 6 weeks, respectively after 6 weeks of supplementation, plasma and heapatic triglyceride and total cholesterol concentrations were decreased significantly (p < 0.05) in TOWE and TOAE groups compared to control group. Fecal total lipid, triglyceride and total cholesterol concentrations were also higher significantly in TO groups compared to control group (p < 0.05), while fecal total lipid, triglyceride and total cholesterol concentrations were lower in TOWE group than TOAE group. Concentration of fecal bile acid was higher in TOAE 1.5% group than the other groups. Superoxide dismutase activity was significantly lower in TO extract groups, but catalase activity and glutathione level were significantly higher in TO groups than control group. sVCAM‐1 concentration was significantly lower in TO extract groups than control group. However, there were no significant changes in MCP‐1, TNF‐ α and IL‐1β among treatments. These results support that Taraxacum officinale may reduce the risk of atherosclerosis via the attenuation of anti‐oxidative, anti‐inflammatory and hypolipidemic processes.