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Sesame oil increases plasma γ‐tocopherol and inhibits its degradation to γ‐CEHC
Author(s) -
LEE SANGEUN,
Frank Jan,
Leonard Scott W,
KamalEldin Afaf,
Traber Maret G
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1112-c
Subject(s) - lignan , chemistry , tocopherol , sesame oil , food science , vitamin e , sesamin , metabolite , corn oil , zoology , sesamum , biochemistry , antioxidant , biology , horticulture , stereochemistry
In rats, sesame lignans increase plasma γ‐tocopherol (γ‐TOH) concentrations and inhibit γ‐TOH degradation to its metabolite γ‐carboxyethylhydroxychroman (γ‐CEHC). To test if sesame lignan consumption inhibits γ‐TOH metabolism in humans, muffins prepared with either corn oil (control) or sesame oil and an equimolar mixture of deuterium labeled d 6 ‐α‐ and d 2 ‐γ‐TOH were administered to male (n=5) and female (n=5) volunteers. TOH and CEHC concentrations were followed for 72 h. Sesame lignan consumption significantly increased plasma d 2 ‐γ‐TOH concentrations (p<0.05). In men, sesame lignans increased the area under the curve (AUC; sesame oil: 34.3 ± 4.6; corn oil: 28.9 ± 3.3 μmol/L·h, p<0.01) of d 2 ‐γ‐TOH and reduced d 2 ‐γ‐CEHC AUCs in plasma (p<0.05). The differences in urinary d 2 ‐γ‐CEHC AUCs in men did not reach statistical significance (AUCs for 24 h, corn oil: 11.2 ± 3.0 μmol/g creatinine·h; vs sesame oil: 5.0 ± 1.5). In women, sesame lignan consumption did not alter plasma TOH and CEHC concentrations but reduced urinary d 2 ‐γ‐CEHC excretion (AUCs for 24 h, corn oil: 19.3 ± 4.9 μmol/g creatinine·h; and sesame oil: 7.7 ± 2.0, p < 0.05). These data suggest that sesame lignans alter γ‐TOH metabolism differently in men and women.