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Which diet prevents mammary carcinogenesis?
Author(s) -
Pereira Paula Cardoso,
Cabrita Antonio Silvério,
Silva Teresa,
Mesquita Maria Fernanda,
Saldanha Helena
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1094-c
Subject(s) - dmba , cancer , breast cancer , endocrinology , medicine , carcinogenesis , zoology , physiology , biology
Studies in animals support the idea that caloric restriction reduces incidence and multiplicity of mammary cancer. Also diets high in fiber have been hypothesized to protect against breast cancer. This study intended to establish the relation between two types of diets with different energetic value and fiber content in the number, volume of breast cancer tumours, and in estradiol levels. Two groups of Sprague‐Dawley rats (n=48; 50 days) were divided and housed 4 in each plastic cage in a holding room under constant conditions of 22o±2oC, 55±10% humidity and a 12 h light/dark cycle. In all animals were administrated 20 mg of 7,12 dimethylbenzanthracene (DMBA) in olive oil, by gavages, had free access to water and food. Diets consisted in a standard food with 300 Kcal/100g (Group I) and a richer fiber food with 250 Kcal/100g (Group II). Sacrifice ended in 150 days. Weight gain was monitored every two weeks. A blood sample was collected before administration of DMBA and in sacrifice. Neoplastic lesions were evaluated according to morphologic features described in rat mammary carcinomas. A significant difference (p<0,001) was observed in weight gain. A high significance (p<0,0001) was observed for mammary tumours number and estradiol levels (p=0,002). These results suggest that a lower energy diet couldn’t be a restriction diet, however a rich fiber diet may prevent mammary carcinogenesis.