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Effects of Flos Sophora Japonica Linne on the Regional Cerebral Blood Flow and Blood Pressure in Rats
Author(s) -
JIN PARk SUNG,
Hahm TaeShik
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1086-b
The purpose of this study was to measure the changes of regional cerebral blood flow(rCBF) and blood pressure(BP) in rats, following the intravenous injection of Flos Sophora Japonica L. water extract. The measurement was continually monitored by laser‐doppler flowmeter and pressure tranducer in anesthetized adult Sprague‐Dawley rats for 2 hours to 2 hours and a half through the data acquisition system composed of MacLab and Macintosh computer. Flos Sophora Japonica L. increased the changes of rCBF in rats significantly. The rCBF of Flos Sophora Japonica L.did not change by pretreated propranolol, atropine, L‐NNA and indomethacin. But the rCBF of Flos Sophora Japonica L.was increased by pretreated methylene blue. Flos Sophora Japonica L. decreased the changes of BP, significantly. The BP of Flos Sophora Japonica L. did not change by pretreated propranolol, atropine, L‐NNA and indomethacin. But the BP of Flos Sophora Japonica L.was decreased by pretreated methylene blue. There results indicated that Flos Sophora Japonica L. can increase the rCBF and decreaed the BP, that is related to guanylyl cyclase activity.