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Effects of Fermented Milk Supplement with Bonnet Bellflower (Codonopsis Lanceolata) Roots on Blood Lipid Profiles in Postmenopausal Rat Model
Author(s) -
CHANG KYUNG JA,
CHEONG SUN HEE
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1085-d
Subject(s) - ovariectomized rat , triglyceride , medicine , endocrinology , cholesterol , chemistry , blood lipids , calcium , estrogen
The purpose of this study was to investigate the effects of fermented milk supplement containing bonnet bellflower roots on serum lipid profiles in postmenopausal rat model. Twenty‐three female Sprague‐Dawley rats weighing 200g were ovariectomized and then were randomly divided into three groups (OVX group; ovariectomized and fed low calcium diet, OVX‐C group; ovariectomized and fed standard diet of basic AIN‐76, OVX+BS group; ovariectomized and fed fermented milk supplement containing bonnet bellflower roots). Rats were fed a low calcium diet for three weeks. After three weeks, rats of the OVX group were sacrificed and those of the other groups were fed a standard diet alone or a standard diet plus fermented milk supplement containing bonnet bellflower roots for 4 weeks. Serum triglyceride, total cholesterol and LDL‐cholesterol levels in the OVX+BS group were significantly lower than the OVX group. Serum HDL‐cholesterol level was significantly higher in the OVX+BS group compared to the OVX and OVX‐C groups. The ratio of HDL‐cholesterol to total cholesterol was significantly higher in the OVX+BS group compared to the OVX‐C group. The ratio of LDL‐cholesterol to HDL‐cholesterol was significantly lower in the OVX+BS group compared to OVX‐C group. These findings suggest a possible anti‐hyperlipidemic effect of fermented milk supplement containing bonnet bellflower roots on the blood lipid profiles in ovariectomized rats.