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Effects of Fermented Milk Supplement with Bonnet Bellflower (Codonopsis lanceolata) Roots on Bone Metabolism in Postmenopausal Osteoporosis Rat Model
Author(s) -
CHANG KYUNG JA,
CHEONG SUN HEE
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1083
Subject(s) - ovariectomized rat , osteoporosis , medicine , bone mineral , osteocalcin , endocrinology , calcium , femur , bone remodeling , chemistry , alkaline phosphatase , surgery , estrogen , biochemistry , enzyme
The purpose of this study was to examine a preventive effect of fermented milk supplement containing bonnet bellflower roots on osteoporosis in postmenopausal women. Twenty‐three female Sprague‐Dawley rats weighing 200g were randomly divided into three groups (LCD group; low calcium diet, OVX‐C group; ovariectomized control, OVX+BS; ovariectomized and then fed fermented milk supplement containing bonnet bellflower roots) and each were fed a low calcium diet for three weeks. Femur and lumbar length in OVX+BS group were significantly higher than OVX‐C group (p<0.05). Bone mass in OVX+TS group was significantly higher than the LCD group (p<0.05). Also calcium levels of femur and lumbar in OVX+BS group were significantly higher compared to the OVX‐C group (p<0.05). The breaking force of OVX+BS group was significantly higher than the other groups (p<0.05). The bone mineral density (BMD) in the OVX+BS group was significantly higher than LCD group (p<0.05). Serum osteocalcin level and alkaline phosphatase activity were not significantly different among the all groups. In conclusion, this study demonstrates that fermented milk supplementation with bonnet bellflower roots may be effective in suppressing bone loss due to ovariectomy.