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Effect of Salicornia herbacea Supplementation on the Kidney Damage in Puromycin Aminonucleoside‐treated Rats
Author(s) -
Son ChangMin,
Kang MiSeon,
Choi HyunJin,
Lee DongSeok,
Choi Hyunju,
Kim YongHo
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1080-a
Subject(s) - puromycin , glomerulosclerosis , glomerulus , endocrinology , fibrosis , medicine , kidney , saline , proteinuria , pathology , chemistry , biochemistry , protein biosynthesis
This study investigated the effects of Salicornia herbacea on chronic glomerular sclerosis in puromycin aminonucleoside (PAN)‐induced rats. Male Sprague‐Dawley rats were divided into a PAN treated group or a saline control group. Each group then was treated with either a diet supplemented with 5% and 10% Salicornia herbacea or Solu‐medrol as a therapeutic control for 13 weeks. Urine albumin, serum triglyceride and total cholesterol levels were elevated in the PAN group (p<0.05). The segmental sclerosis in the glomerulus, adhesion with fibrosis in the Bowman’s capsule, mild lymphocytic infiltration, and fibrosis with tubular atrophy in the interstitium were also observed. In the Solumedrol treated and Salicornia herbacea supplemented group, less increase in serum triglyceride and total cholesterol, and less severe or even no glomerular sclerosis were shown (p<0.05). Damages in the glomerular cells were repaired by Salicornia herbacea . We concluded that Salicornia herbacea is effective in protecting glomerular sclerosis of PAN‐induced kidney damage. (Supported by BPRC)