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Associations of dietary intake and physical activity with intramyocellular lipid content in older men and women
Author(s) -
Hauk Gracen,
Sullivan Dennis H,
Evans William J,
Hakkak Reza,
Harris Margaret M,
Carroll Polly A,
Hays Nicholas P
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1069
Subject(s) - medicine , endocrinology , skeletal muscle , trunk , insulin resistance , overweight , fructose , diabetes mellitus , chemistry , obesity , biology , food science , ecology
Lipid accumulation within skeletal muscle has been associated with insulin resistance, functional disability, and aging. We examined associations of dietary intake and physical activity with intramyocellular lipid (IML) content in 49 overweight (BMI 29.9 ± 3.5 kg/m2) subjects (20 M/29 F) aged 55–80 y. Computed tomography of trunk (mean of rectus abdominis, paraspinals, and lateral abdominals) and thigh (mean of quadriceps and hamstrings) muscle was used to determine skeletal muscle attenuation (a marker of IML content). Habitual dietary intake and physical activity patterns were assessed using 5‐d weighed food records and the Yale Physical Activity Survey for Older Adults. Total dietary energy and macronutrient intakes were not significantly associated with skeletal muscle attenuation. Dietary intake of both glucose (r=0.346, P<0.05) and fructose (r=0.333, P<0.05), adjusted for energy intake, were independently correlated with trunk muscle attenuation, indicating that greater intakes were associated with less IML content. Dietary intake of vitamin D was negatively associated with thigh muscle attenuation (r=−0.302, P<0.05). Physical activity variables were not associated with IML content in the trunk or thigh. These results suggest that dietary glucose, fructose, and vitamin D intakes may regulate the accumulation of skeletal muscle fat. NIH RO1AG15385, F32AG21374, MO1RR14288, and UAMS MRE.