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Plasma fatty acids are associated with circulating adiponectin in overweight adolescent girls
Author(s) -
Gallo Sina,
Egeland Grace,
Meltzer Sara
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1064
Subject(s) - adiponectin , overweight , endocrinology , medicine , insulin resistance , obesity , fatty acid , polyunsaturated fatty acid , gestational diabetes , chemistry , biology , pregnancy , biochemistry , gestation , genetics
Objective: Recent evidence suggests insulin resistance develops as a result of dietary fat quality and plasma fatty acids are a good marker to reflect recent dietary exposure. Adiponectin could be involved in the pathway in which dietary fatty acids influence insulin sensitivity. The purpose of this study was to describe how dietary fatty acids impact adiponectin concentrations. Methods: We examined the plasma fatty acids of 180 adolescent daughters born to mothers with and without gestational diabetes. Overweight was defined as ≥ 85th percentile based on CDC 2000 BMI‐for‐age growth charts. Fasting adiponectin concentrations were measured using a commercial assay. Results: There were no differences in fatty acid concentrations between normal weight and overweight adolescents. However, the relation between fatty acids and adiponectin varied by body weight. Among the overweight teens, n‐6 fatty acids were positively related with circulating adiponectin (r = 0.36, P = 0.01). In addition, adiponectin was significantly and negatively associated with monounsaturated fatty acids (r = −0.29, P = 0.04) and n‐3 fatty acids (r = −0.35, P = 0.01). Conclusions: Obesity may impact the relationship between markers of fat intake and adiponectin. Unlike previous findings in healthy subjects, n‐3 is inversely associated with circulating adiponectin levels in overweight adolescent girls. Obesity and insulin resistance have been proposed to result in alterations of fatty acid desaturase activities leading to differences in fatty acid composition thus potentially explaining these findings in this subgroup of adolescents. CIHR Funding.