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Effects of Splenda® Brand Sweetener on plasma hormone and metabolite concentrations
Author(s) -
Brown Andrew W,
Bohan Michelle M,
Onken Kristine L,
Beitz Donald C
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1060-a
Subject(s) - metabolite , chemistry , food science , hormone , biochemistry
Artificial sweeteners have been used to help deter the increase in instances of obesity but have often been met with concerns about their effects on metabolism and nutrient intake. In the present study, eight women ages 20–25, were given one treatment beverage consisting of water, sucrose, Splenda® Brand Sweetener (Splenda®), or both sucrose and Splenda® (Both), on each of four days. Blood was drawn via intravenous catheter prior to consuming the beverage, and 30 and 60 min after consuming the beverage. A balanced, 500 calorie breakfast was administered thereafter, and blood was collected 30, 60, 90, and 120 min after the breakfast was consumed. A visual analogue scale was administered prior to each blood draw to determine feelings of hunger, tiredness, gastrointestinal wellbeing, and overall wellbeing. Plasma was analyzed for glucose, insulin, ghrelin active, triglycerides, and glucagon. We hypothesized that energy homeostasis and desire for nutrient intake would be similar between water and Splenda®, between sucrose and Both, but not between these two pairs. In general, subjects responded similarly between water and Splenda® and between sucrose and Both before breakfast, while responses were similar among the four groups after breakfast. We conclude that the consumption of Splenda® results in responses similar to water without effecting nutrient processing when consumed before a meal.