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Effect of fructose or sucrose administration with different levels in oral glucose tolerance in Goto‐Kakizaki rats
Author(s) -
Kwon Sanghee,
Son Youngae,
Kim Mi Kyung
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1059-b
Subject(s) - fructose , sucrose , glycemic , medicine , endocrinology , blood sugar , sugar , blood sampling , chemistry , diabetes mellitus , food science
This study was designed to determine whether acute fructose or sucrose administration at different levels (0.05 g/kg, 0.1 g/kg, 0.4 g/kg body weight) might affect oral glucose tolerance in diabetic Goto–Kakizaki (GK) rats. Seventy male six‐week aged GK rats were fed with a normal diet for seven days of adaptation before testing. Addition of fructose to the glucose load tended to reduce glycemic response to the oral glucose tolerance test (OGTT). The increment in blood glucose after the sugar (addition of fructose or sucrose to the glucose) load was expressed in terms of the area under the curve (AUC) from the time when the fasting blood was drawn until the 120 min. postload blood sampling. The AUCs of fructose‐fed groups were lower than those in the sucrose‐fed groups, and the AUC of fructose‐fed animals was decreased with decreasing fructose dose level administration. Only the AUC of 0.05g/kg fructose‐fed group was lower than control. Nevertheless, there were no significant differences in the glucose response between acute fructose‐ or sucrose‐fed groups. In conclusion, the addition of a small amount of fructose to a glucose load improved glucose tolerance in diabetic GK rats. ∗This work was supported by the grants from Daesang.Co.Ltd. and the second stage of Brain Korea 21 project in 2006.