Adiponectin Gene Polymorphism (SNP276G>T) is Associated With Impaired Glucose Tolerance

Adiponectin is fat‐cell derived hormones, which is thought to be respectively protective and disadvantageous with regard to the development of cardiovascular disease (CVD) and diabetes mellitus type 2. A number of genetic variations have been studied. Among them, single nucleotide polymorphism, SNP276G>T of adiponectin gene showed an association with type 2 diabetes in different ethnic groups. The aim of the study is to examine associations between genetic variations of SNP 276 G>T with glucose tolerance status in 683 Taiwan aborigines from Southern Taiwan. Normoglycemia was classified as fasting glucose levels <110 mg/dl and hyperglycemia was ≧ 126 mg/dl. The T‐allele frequencies were significantly associated with hyperglycemic state (p<0.01). After adjusting for confounding factors, waist ≧90 cm (OR=2.54, 95% CI=1.26–5.14) and SNP276 T allele carrier (OR=2.3, 95% CI=1.24–4.34) were independently associated with risks of impaired glucose tolerance status. On the other hand, adiponectin ≧ 10.9 ug/ml (OR=0.41, 95% CI=014–0.98) was negatively correlated. In conclusion, the SNP276 of the adiponectin gene and waist circumference may predict the increasing risk for impaired glucose tolerance state in general population. This project is supported by a grant, NSC94‐2320‐B‐037‐038, from National Science Council in Taiwan.