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Relationship Between The Cellular Traffic From Mothers To Fetus And HBV Intrauterine Transmission
Author(s) -
Wang Suping,
Wei Junni
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.6.a1045
Subject(s) - fetus , hbsag , peripheral blood mononuclear cell , medicine , obstetrics , transmission (telecommunications) , pregnancy , immunology , hepatitis b virus , biology , genetics , virus , in vitro , electrical engineering , engineering
Objective: To explore the possible relationship between cell transfer from mothers to fetus and HBV intrauterine infection. Methods: Maternal and fetal DNA were amplified by STR‐PCR£¬As‐PCR, and hemi‐PCR. Cell transfer was determined by detecting fetal TH01, GSTM1, and ACE. The relationship between cell transfer and HBV intrauterine infection was analyzed by nested case‐control study. Results: 26 of the 42 informative mother‐baby pairs indicated cell traffic from mother to baby while 32 of the 40 informative mother‐baby pairs indicated cell traffic from fetus to mother. Two‐way cell traffic occurred in 10 mother‐baby pairs. Statistical analysis demonstrated that cellular traffic from mothers to fetus, but not from fetus to mothers, presented an association with HBV intrauterine infection. Both mothers‐to‐fetus cell traffic and peripheral blood mononuclear cell(PBMC) HBV DNA positive in pregnant women were the risk factors of HBV intrauterine infection. Conclusions: Cell traffic from HBsAg positive mothers to fetus had more contribution to HBV intrauterine infection. This suggests it may be one of the HBV intrauterine infecting routes.