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Supplementation with Docosahexaenoic Acid (DHA) in Women with Gestational Diabetes Mellitus (GDM) in Chile: Benefit to Glucose Tolerance and Plasma Lipids
Author(s) -
LammiKeefe Carol J,
Parodi Carmen Gloria,
Foncea Rocio,
Sobrevia Luis,
Gonzalez Marcelo,
Oyarzun Enrique,
Garces Patricia,
Nunez Erwin,
Acosta Ana Maria,
Caceres Marisol,
Rozowski Jaime
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a98-a
Subject(s) - docosahexaenoic acid , gestational diabetes , medicine , endocrinology , placebo , insulin resistance , gestation , blood lipids , diabetes mellitus , incidence (geometry) , polyunsaturated fatty acid , insulin , pregnancy , cholesterol , fatty acid , chemistry , biology , biochemistry , genetics , alternative medicine , physics , pathology , optics
Dietary supplementation of healthy pregnant women with DHA, benefits both the mother and baby. Women with GDM have exaggerated plasma lipids that accompany their insulin resistance and their infants have DHA concentrations that are approximately one‐half those of infants born to women without GDM (Wijendran et al, 2000), GDM in Chile has an incidence that is documented at approximately 19% with screening in both the 2 nd and 3 rd trimesters. In this study we examined the effect of supplementation with 600 mg of DHA on parameters that are altered in GDM. Women with GDM (n=15) were supplemented with 600 mg/d of DHA (n=6) or placebo (n= 9) beginning at 24–30 wks of gestation; case histories were recorded and blood samples were collected for the determination of lipids and HbA1c. Blood collections were repeated at 36 wks. There were no differences between groups in plasma lipids or HbA1c at the beginning of the study. At 36 wks the placebo group had a significantly higher increase in total cholesterol, LDL‐cholesterol and HbA1c compared to the DHA group (24.3 mg/dl vs. 3.4 mg/dl, p<0.05; 16.6 mg/dl vs. 0, p<0.05; 0.2 mg/dl vs. −0.22 mg/dl, p<0.05, respectively). These results point to a benefit of DHA supplementation for the mother with GDM. (Supported in part by FONIS SA04I2054 (Chile) and Nestec, Ltd., Switzerland.)