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Metabolic Characterisation of PGC1b Ko mice
Author(s) -
VidalPuig Antonio J
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a91-c
Subject(s) - regulator , oxidative phosphorylation , biology , oxidative stress , mitochondrion , microbiology and biotechnology , homeostasis , function (biology) , gene , biochemistry
We have investigated the function of PGC‐1b by generating and phenotyping a mouse model lacking PGC‐1b (the PGC1bKO mouse). Using a combination of physiological experiments guided by a systems biology approach, we show that PGC‐1b plays a general role in regulating the mitochondrial activity in tissues with active oxidative metabolism. In all tissues studied, lack of PGC‐1b was associated with a reduction in the expression of mitochondrial genes, including intermediary subunits and enzymes connected to ETC and oxidative phosphorylation (OxPhos). Despite these mitochondrial defects, the PGC1bKO mouse was able to cope when challenged with a range of physiological stressors including cold acclimatisation and adrenergically‐mediated BAT and cardiac stimulation but with abnormal compensatory responses. Altogether these data suggest that generally PGC‐1b is an important regulator of basal energy homeostasis and essential for the proper metabolic tuning in acute stress situations in multiple organs.