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Extracellular Matrix Degradation by Invadopodia
Author(s) -
Weaver Alissa,
Clark Emily
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a91
Subject(s) - invadopodia , cortactin , microbiology and biotechnology , extracellular matrix , podosome , actin , chemistry , biology , cancer cell , biochemistry , cytoskeleton , cancer , cell , genetics
Invadopodia are branched actin‐rich cellular structures that degrade extracellular matrix (ECM). The ability to form invadopodia is thought to be essential for cancer cells to invade across basement membrane barriers. Molecular components of invadopodia include actin assembly molecules, src kinase and associated signaling molecules, adhesion proteins, and matrix‐degrading proteinases; however integration of these molecules into a functional invasive machinery is poorly understood. Our recent studies have focused on cortactin, a prominent component of invadopodia and branched actin regulator. Surprisingly, we find that cortactin is essential for ECM degradation at invadopodia and secretion of invadopodia‐associated matrix metalloproteinases, but not for initial actin assembly in invadopodia. Furthermore, we identify a positive feedback role for matrix metalloproteinases in the formation of new invadopodia. These data suggest a new model of invadopodia function, in which positive feedback from ECM‐invadopodia interactions leads to increased invasive behavior.