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Optical Coherence Tomography: an emerging technology for functional imaging in embryonic cardiovasculature
Author(s) -
Davis Anjul M,
Rothenberg Florence,
Izatt Joseph A
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a88-a
Subject(s) - optical coherence tomography , blood flow , laser doppler velocimetry , doppler effect , biomedical engineering , embryonic heart , velocimetry , preclinical imaging , tomography , functional imaging , doppler imaging , medicine , embryonic stem cell , in vivo , optics , radiology , physics , biology , blood pressure , biochemistry , microbiology and biotechnology , diastole , astronomy , gene
We have developed optical coherence tomography (OCT) for quantification of blood flow through the embryonic cardiovascular system. OCT is a non‐invasive technique capable of real‐time acquisition of high‐resolution (2–15μm), cross‐sectional images with up to 2mm depth of penetration. Doppler OCT is a functional extension of OCT that enables in vivo imaging of blood flow through heart and vasculature. We have developed spectral Doppler OCT velocimetry for localized quantification of temporal blood flow dynamics in the embryonic cardiovascular system. We present data demonstrating feasibility of this technique. Doppler OCT may provide a valuable tool for non‐invasively measuring blood flow in developing cardiovasculature.