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An in vivo role for neuropilin‐1 in cranial neural crest cell migration
Author(s) -
McLennan Rebecca,
Kulesa Paul M.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a81-b
Subject(s) - semaphorin , neural crest , cranial neural crest , biology , neural tube , neuropilin 1 , microbiology and biotechnology , population , neuroscience , rhombomere , anatomy , embryo , receptor , vascular endothelial growth factor , hox gene , genetics , cancer research , vegf receptors , demography , sociology , gene , transcription factor
During vertebrate development, neural crest cells (NCCs) are a pluripotent population of cells that delaminate from the neural tube and migrate in a stereotypical pattern to specific destinations in the embryo. In the cranial region, the proper migration of cranial NCCs is necessary for the correct formation of craniofacial structures and components of the nervous system, yet the signaling mechanisms that produce the stereotypical migration pattern are still unclear. We are interested in exploring the function of potential cranial NCC guidance factors, and use molecular perturbations and microsurgery in combination with time‐lapse confocal analysis. We examine changes in NCC motility and behaviors in vivo by using an avian model system. I will discuss our investigation of the in vivo role of neuropilin‐1, a co‐receptor for both semaphorin and vascular endothelial growth factor family members, with a focus on the cranial NCC migratory stream that emerges lateral to rhombomere 4 and invades the second branchial arch.