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Avenanthramide bioavailability and liver absorption in rats
Author(s) -
Koenig Ryan,
Dickman Jonathan,
Wise Mitchell L.,
Ji Li Li
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a727-c
Subject(s) - bioavailability , ingestion , avena , chemistry , absorption (acoustics) , plasma concentration , medicine , high performance liquid chromatography , endocrinology , zoology , pharmacology , biology , biochemistry , chromatography , botany , physics , acoustics
Avenanthramides (Avn) are antioxidants found exclusively in oats ( Avena sativa L.). The aim of this study was to determine the time course of Avn absorption into plasma and liver following their ingestion. Avn B p , B f , and B c (20 mg /kg body wt) were fed to female Sprague‐Dawley rats (N=20) by oral gavage. Plasma and liver samples were collected at 1, 2, 4, and 12 h post‐gavage and analyzed with HPLC. B p was the most abundant in the plasma at all time points, reaching peak concentration of 0.698 ppm. In the liver, B p reached peak concentration of 7.236 μg/mg liver at 4 h. Plasma B f was elevated at 1 and 2 h before declining at 4 h. B c concentration peaked at 0.177 ppm in the plasma at 1 h and returned to zero by 12 h, but remained elevated in the liver over the entire time course. At 12 h, only B p remained bioavailable, whereas all three Avn fractions were present in the liver. We conclude that rats have the ability to store Avn despite their elimination from the circulation during the 12‐h post‐absorptive period.