Premium
Relationship of antioxidant nutrients with oxidative protein damage among older women living in the community
Author(s) -
Alipanah Narges,
Ferrucci Luigi,
Sun Kai,
Fried Linda P,
Walston Jeremy,
Varadhan Ravi,
Guralnik Jack M.,
Semba Richard D.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a727-b
Subject(s) - carotenoid , antioxidant , lycopene , selenium , oxidative damage , nutrient , oxidative phosphorylation , chemistry , oxidative stress , medicine , biochemistry , organic chemistry
Background : Selenium, alpha‐tocopherol, and carotenoids are important contributors to the antioxidant defenses, which prevent oxidative damage to enzymes and structural proteins. The most general indicator of the amount of oxidative damage to proteins is the serum protein carbonyl content. Specific Aim : To determine whether serum antioxidant nutrients are inversely associated with oxidative protein damage among older women. Methods : This cross‐sectional study was conducted on 745 women enrolled in the Women's Health and Aging Studies I, the one‐third most disabled women dwelling in the community in Baltimore, MD. Serum selenium, protein carbonyl content, and carotenoids were measured in each patient. Results : In univariate linear regression models, log total serum carotenoids (beta = −0.087, P = 0.016) and log selenium (beta = −0.396, P = 0.0005) were related to log serum protein carbonyls. Of the six major dietary carotenoids, log serum lycopene was most closely associated with log protein carbonyls (beta = −0.107, P <0.0001). Alpha‐tocopherol was not significantly related to protein carbonyls. Conclusion : Total serum carotenoids and selenium levels were inversely correlated with serum protein carbonyl concentrations. This supports the idea that antioxidant nutrients are important in protecting proteins from oxidative damage in older adults. This research was supported by NIH R01 AG027012.