Premium
Effect of β‐carotene supplementation on proliferation of lymphocytes and red blood cell hemolyses in young people
Author(s) -
Ma Aiguo,
Luo Yongbin,
Du Zhen,
Li Yonghua,
Sun Yongye,
Wang Qiuzhen
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a725-c
Subject(s) - placebo , carotene , medicine , beta carotene , vitamin , peripheral blood , placebo group , vitamin e , vitamin c , endocrinology , gastroenterology , immunology , antioxidant , chemistry , biochemistry , food science , pathology , alternative medicine
Objective: To investigate the effect of beta‐carotene supplementation on proliferation of lymphocytes and red blood cell (RBC) hemolyses in young people. Method: One hundred and eighty‐eight young subjects were randomly divided into 4 groups, the fourth group was only supplemented with 5mg/d vitamin E as a placebo. The first, second and third groups were daily supplemented with 5mg/d vitamin E + 16.7mg/d, 8.35mg/d and 5.57mg/d beta‐carotene respectively for 8 weeks. The proliferation of peripheral‐blood lymphocytes (PPL) and the hemolytic degree of RBC induced with H2O2 were measured at the beginning and the end of the trial. Results: After 8 week supplementation, the proliferation of PPL in the first group increased by 30.4% (P<0.05); compared with the control group, it increased by 25.0%(P<0.05). The RBC hemolyses in the middling‐dose group (8.35mg/d) was significantly lower after the trial (P<0.05). Conclusion: The moderate supplementation of beta‐carotene could improve the proliferation of lymphocytes and decrease RBC hemolyses against H2O2 oxidation in young people. Supported by Chinese Nutrition Society Fund and Chinese Natural Science Fund (30571571)