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Cognitive impairment and dementia due to Alzheimer disease and cerebrovascular pathology in autopsied ACT study patients
Author(s) -
Sonnen Joshua Aaron,
Leverenz James B.,
Crane Paul K,
Larson Eric B.,
Montine Thomas Jude
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a72-c
Subject(s) - neuropathology , dementia , cerebral amyloid angiopathy , pathology , population , autopsy , dementia with lewy bodies , alzheimer's disease , medicine , senile plaques , cognitive decline , histopathology , psychology , disease , environmental health
The Adult Change of Thought Study is a population‐based longitudinal prospective study of brain aging and incident dementia in individuals 65 years and older. METHODS: Patients were screened with the Cognitive Assessment Screening Instrument (CASI) and those scoring 85 or less were evaluated by DSM‐IV criteria. Within this population based sample, we collected standard neuropathology endpoints by gross examination, histopathology and immunohistochemistry. RESULTS: In assessment of 221 autopsy brains, cognitive status strongly correlated with Braak stage, isocortical Lewy bodies, and vascular damage, especially number of microvascular lesions. Not strongly correlated with cognitive status was amyloid angiopathy, neuritic plaque score, number of cystic infarcts or midbrain Lewy bodies. CONCLUSION: This confirms key findings from previous studies of focused groups in a population based sample and establishes the structural correlates of cognitive impairment in a general population in the US.