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The effects of dietary carnitine on blood and organ carnitine concentrations in the piglet
Author(s) -
Pang John,
Borum Peggy
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a716-a
Subject(s) - carnitine , colostrum , medicine , endocrinology , metabolism , compartmentalization (fire protection) , essential nutrient , nutrient , chemistry , biology , zoology , biochemistry , immunology , enzyme , organic chemistry , antibody
Carnitine is well known for its role in fatty acid metabolism. CARN may be a conditionally essential nutrient for the developing neonate. Many studies evaluating the effect of supplemental CARN monitor plasma CARN assuming it reflects tissue CARN. The objective was to use a piglet model to determine the effect of dietary CARN on blood and tissue CARN and analyze possible compartmentalization of CARN. Blood and organs were obtained from colostrum‐deprived piglets at birth (B), or at day 4 after being fed sow's milk (M4)or formula with or without supplemental CARN (C4 and CF4, respectively). A sow's milk diet increased CARN in each of the compartments listed in Table 1. However, C4 formula only increased muscle, liver, plasma, and RBC CARN. A CF4 formula only led to increases in the muscle and liver, suggesting that these two organs can accrete CARN obtained via biosynthesis instead of the diet. Examination of the Z‐tiles shows that the parameters presented above demonstrate different accretion patterns dependent upon the diet fed, suggesting that they may be separate compartments of CARN. 1 Summary of M4, C4, and CF4 Z‐tiles