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Effect of L‐carnitine feeding with different level on lipid metabolism in obese adult rats
Author(s) -
Kim Ja Kyung,
Shim Jee Ae,
Kim Mi Kyung
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a715-b
Subject(s) - carnitine , endocrinology , medicine , lipid metabolism , feces , metabolism , calorie , chemistry , cholesterol , obesity , biology , paleontology
This study investigated optimal level of L‐carnitine for lipid metabolism in obese adult rats. Sprague‐Dawley male rats (n=90, 8‐month‐old) fed 40% fat diet to induce obesity for 4 wks. The rats were blocked into nine groups and fed experimental diet containing non L‐carnitine(NC), 0.5% L‐carnitine(LC), 2.5% L‐carnitine(HC) for 8 wks. Each of three groups was allotted to control, low lysine and low lysine with pivalate respectively. Carnitine palmitoyltransferase1 (CPT1) activity, lipid concentrations in plasma, liver and feces were measured. Daily calorie intake, calorie efficiency ratio and total lipid level of liver and fecal excretions in HC groups were lower than those of NC and LC groups regardless of both low lysine and pivalate. CPT1 activity was not significantly different among all groups. Plasma HDL‐cholesterol concentrations of HC groups were significantly higher than NC and LC groups. In conclusion, high level of L‐carnitine seemed to increase plasma HDL‐cholesterol level and improve lipid metabolism in liver and fecal excretions. *This work was supported by the second stage of Brain Korea 21 project in 2006