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Oral taurine supplementation does not increase muscle taurine content or alter substrate metabolism during prolonged submaximal cycling in active males
Author(s) -
Galloway Stuart D.R.,
Talanian Jason L.,
Shoveller Anna K.,
Heigenhauser George J.F.,
Spriet Lawrence L.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a715-a
Subject(s) - taurine , medicine , endocrinology , ingestion , glycogen , metabolism , skeletal muscle , chemistry , carbohydrate metabolism , metabolite , amino acid , biochemistry
This study was designed to determine if 7 days (d) of oral taurine supplementation would increase muscle taurine content at rest, and alter substrate metabolism during 2 hr of cycling at 60% of VO 2 max. Eight active males (mean ± SD, 22±1yr, 181.3±2.4cm, 80.9±10.6kg) cycled for 2 hr after 7 d of placebo (PL) ingestion (6g glucose/d) and again following 7 d of taurine (T) ingestion (6g/d). Skeletal muscle biopsies obtained from the vastus lateralis immediately prior to and following exercise revealed no effect of T supplementation on muscle taurine content (mmol/kg dry muscle) at rest (PL, 43.8±15.2 vs. T, 41.7±14.6) or after exercise (PL, 42.6±11.7 vs. T, 43.3±10.8). No difference was observed between conditions in pre and post‐exercise muscle glycogen or muscle metabolite contents (lactate, PCr, Cr, ATP, ADP f , AMP f , acetyl CoA and acetylcarnitine). Substrate use assessed by respiratory exchange was unaffected by T supplementation (total carbohydrate oxidation (g/hr); PL, 102±45 vs. T, 97±45, and fat oxidation; Pl, 24±12 vs. T, 23±10). Blood lactate and glucose responses to exercise were not different between conditions. Additional plasma and muscle amino acid concentrations were also unaffected by taurine ingestion. These data indicate that dietary taurine supplementation does not alter skeletal muscle taurine content at rest and has no effect on substrate metabolism during prolonged submaximal cycling.