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Influence of inflammation on serum retinol levels in gastroenterological surgical patients.
Author(s) -
Zago Liliana,
Danguise Eduardo,
Infantino Carlos González,
Callegari Mariana,
Dupraz Hernán,
Río Maria Esther
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a706-c
Subject(s) - inflammation , medicine , gastroenterology , c reactive protein , vitamin a deficiency , vitamin , retinol
Serum retinol (R) is the most reliable marker to evaluate vitamin A nutritional status. It is accepted that inflammation result in a serum level decrease that may conduce to a deficiency that current knowledge does not even define as functional or as apparent. In order to evaluate the influence of inflammation on R levels in surgical patients with no infection, 45 patients from programmed gastroenterological surgeries were studied. R was determined by HPLC and C‐Reactive Protein (CRP) by commercial kits as a marker of inflammation (CRP positive when >0.6 mg/dl; I+) in fasting samples taken before surgical procedure. Patients with no inflammation (I−; n=28) presented a X±SD of 49.5±19.1 μg/dl; distribution of values showed none patient with values <20 μg/dl indicatives of deficiency, 7% of values <30, considered sub‐optimal, and 3.5% of values <25, founded as associated with increased risk of complications in a previous work. Patients with inflammation (I+; n=17) presented a X±SD of 35.6±16.1μg/dl, significantly lower than that of I− (P=0.0162); 18% of values were <20, 53% <30 and 23% <25μg/dl. We conclude that chronic inflammation with no infection expose the patient to a higher chance of deficiency, that if traduced in low utilization by peripheral tissues, may compromise evolution by increasing the risk of complications. Supported by UBACyT B077.