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Association of body mass index and pulmonary function tests in cystic fibrosis patients
Author(s) -
Bennett Megan,
Harris Margaret M,
Carroll Polly,
Hays Nicholas,
Anderson Paula J,
Hakkak Reza
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a706-b
Subject(s) - medicine , cystic fibrosis , body mass index , pulmonary function testing , gastroenterology , lung function , diabetes mellitus , lung , endocrinology
Few studies have utilized data on adults with cystic fibrosis (CF) to investigate nutritional status with pulmonary function. The purpose of this study was to examine whether BMI is associated with pulmonary function in 71 CF patients adjusting for effects of pseudomonas aeruginosa, pancreatic insufficiency, and CF‐related diabetes. Data was collected via chart audit from patients aged 18+y via who had at least 2 visits over a 4‐y period (2002–2005). Paired t‐tests were used to calculate differences between the first and last visit. Patients (avg age 26.3+7.5) had an average of 3 visits per year and had abnormal lung function at baseline. Patients with pancreatic insufficiency had lowest BMIs (21.3 kg/m2) compared to those without (23.6 kg/m2, p=0.02) In people who were followed for all 4 years (n=30), pulmonary function significantly declined (FVC 3.4 vs 3.1, p=0.01; FEV1 2.3 vs 2.0, p<0.0001; %predicted FVC 75.0 vs 70.0, p=0.07; and % predicted FEV1 60.9 vs 53.5, p=0.002). BMI remained relatively constant (21.8 kg/m2 baseline vs 22.4 kg/m2 last visit, p=NS). Aggressive nutritional interventions may have played a role in BMI maintenance. Further studies are warranted to better determine the relationship between nutrition and lung function.