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Impact of Increased Energy Intake After Acute Hypo‐Energetic Dieting on Markers of Energy Balance, Satiety and Fuel Utilization in Obese Females.
Author(s) -
Kerksick Chad,
Roberts M,
Taylor L,
Moulton C,
Rasmussen C,
Kreider R
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a693
Subject(s) - leptin , medicine , endocrinology , ghrelin , dieting , adiponectin , insulin , obesity , calorie , weight loss , insulin resistance , hormone
The consumption of diets with increasing caloric intakes after acute hypo‐energetic dieting on serum weight management markers were examined. Sedentary, obese women (n=122) for 7d consumed either their normal diet (CON, n=14), a higher carbohydrate (%CHO: PRO: FAT= 46: 24: 30; n=52) or higher protein (%CHO: PRO: FAT= 24: 46: 30; n=56) hypocaloric (HYPO) diet (1,000 kcal·d −1 ). Subjects then consumed for 7d either 1,600 (n=27), 2,100 (n=26), 2,600 (n=30), or 3,100 (n=25) kcal·d −1 consisting of (%CHO: PRO: FAT= 55: 15: 30) while CON maintained their normal diet. After 7 and 14d of dieting, participants provided fasting blood samples for determination of body mass, serum insulin, leptin, adiponectin and ghrelin levels. Data were analyzed by Pearson correlations and repeated measures ANOVA using an alpha level of 0.05. Adiponectin levels did not change (p<0.05) and no changes were reported relative to macronutrient intake through the first week of dieting. Significant but equal weight loss occurred in both HYPO groups, while leptin increased and insulin decreased in all groups. Ghrelin and leptin levels increased in all groups after increasing caloric intake. A significant interaction effect was found for leptin, with the 3,100 calories and CON group reporting higher levels of leptin in comparison to all other diet groups. Ghrelin in all groups was greater after dieting in comparison to baseline. Leptin was correlated to changes in body mass (r=0.409; p<0.01) and insulin (r=0.369;p<0.01). Initial HYPO dieting decreased body mass, insulin and leptin levels while adiponectin was unchanged. Increased caloric intake increased leptin levels in conjunction with caloric intake.