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Oxidative protein damage is associated with poor grip strength among older women living in the community
Author(s) -
Howard Caitlin Therese,
Ferrucci Luigi,
Sun Kai,
Fried Linda P,
Walston Jeremy,
Varadhan Ravi,
Guralnik Jack,
Semba Richard D
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a685-d
Subject(s) - grip strength , protein carbonylation , sarcopenia , medicine , oxidative stress , hand strength , body mass index , depression (economics) , weakness , activities of daily living , multivariate analysis , gerontology , oxidative damage , physical therapy , surgery , economics , macroeconomics
Background: Grip strength, an indicator of muscle strength, has been shown to be a predictor of poor outcomes among older adults. Protein carbonylation, an indicator of oxidative damage to proteins, leads to cellular dysfunction and a decline in tissue function, and oxidative stress is thought to be involved in the pathogenesis of sarcopenia. Specific Aims: The objective was to determine whether serum protein carbonyl concentrations are associated with grip strength in older women living in the community. Methods: A cross‐sectional study was conducted in 672 women, aged 65 and older, from the Women's Health and Aging Study (WHAS) I, the one‐third most disabled women residing in the community in Baltimore, Maryland. Protein carbonyl and grip strength was measured in each patient. Results: In a multivariate analysis adjusting for age, race, body mass index, and Mini‐Mental Status Examination score, protein carbonyls levels are associated with grip strength (beta = −6.77, p < 0.01). Additional adjustment for hypertension, congestive heart failure, and depression in the multivariate analysis produced similar results. Conclusion: These results suggest oxidative protein damage is independently associated with low grip strength among older women living in the community. Increased oxidative stress may be contributing to loss of muscle strength in older adults. This research was supported by NIH R01 AG027012.