Premium
Antibacterial properties of newly synthesized 4‐ pyrimido‐ 2‐oxo‐2H‐chromen‐3‐carbaldehydes
Author(s) -
GovoriOdai Sevdije R.,
Spahiu Sabrie,
Haziri Arben I.
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a627
Subject(s) - triethylamine , chemistry , acetone , staphylococcus aureus , catalysis , antibacterial activity , escherichia coli , organic chemistry , combinatorial chemistry , bacteria , biochemistry , biology , genetics , gene
Refluxing of of 4‐chloro‐ 2‐oxo‐2H‐chromen‐3‐carbaldehyde 1, pyrimidinylamines 2–4 (2‐amino‐4,6‐ dimethylpyrimidine, 6‐amino‐2,4‐hydroxypyrimidine and 5‐amino‐4,6‐dichloropyrimidine) and the catalytic amount of triethylamine in acetone gave the corresponding (pyrimidin‐2‐ylamino)‐2‐oxo‐2H‐chromen‐3‐carbaldehydes 5–7 in high yields. The identity of compounds 5–7 has been with spectral data and elementary analysis. During the research work of microbiological activity of newly synthesized compounds is proved that these compounds obviously inhibit the growth of: Escherichia coli ATCC 25922; Staphylococcus aureus ATCC 25923 and Enterobacter Cloaca PTCC 2005. These compounds 5–7 don't show activity against Pseudomonas aeroginosa 27853 and Hafnia alvei PTCC 2005.