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Eating Pattern and Dietary Composition Associations with Insulin Resistance (IR) Markers
Author(s) -
Evezich Maribeth,
Solages F,
Gilhooly C,
Eldridge G,
Huang T,
Gehrke M,
Roberts S,
Saltzman E,
Fuss P,
Koutoubi S,
Murdoch S,
McCrory M
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a6-c
Subject(s) - glycemic load , glycemic , waist , glycemic index , insulin resistance , confounding , medicine , zoology , body mass index , endocrinology , insulin , chemistry , biology
We investigated dietary factors suggested to influence glucose homeostasis in relation to markers of IR, including waist circumference (WC), and HOMA and QUICKI (calculated from fasting insulin and glucose). Data from two studies with similar methodologies were used (n=28 healthy adults aged 37.4 ± 6.4 y (mean ± SD); BMI 20‐32 kg/m 2 ). Three multiple‐pass 24‐hour recalls were used to assess dietary variables, including glycemic index (GI; estimated using the formula of Wolever et al (1994)) and glycemic load (GL; calculated as described by Flood et al (2006)). Dietary records were highly plausible: reported energy intake was 91 ± 28 % of predicted energy requirements (mean ± SD). Other dietary values were GI (82 ± 5), GL (197 ± 62), fiber density (8.6 ± 3.1 g/1000 kcal), and eating frequency (4.8 ± 1.3 times/d). HOMA ranged from 0.7 to 6.5 μU.ml −1 *mmol/L. In regression analysis controlled for confounders, GL was the dietary factor most strongly associated with WC (β =0.052 ± 0.024, partial R 2 =0.37, p=0.065, model p<0.012). ANOVA revealed that a high fiber density coupled with a low GL was associated with the lowest WC (p=0.021). No dietary factors were associated with HOMA or QUICKI, but %BF best predicted IR as indicated by QUICKI (partial r= ‐0.44, p=0.04). Further work is needed to determine the relative importance of different dietary factors associated with IR. Funded in part by ILSI and DK062400 .