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Enantiomers of Z‐Bisdehydrodoisynolic Acid: Effects on Traumatic Brain Injury in Young Adult Male Rats
Author(s) -
James Bryce,
Neese Steven,
Banz William,
Meyers Cal,
Hou Yuqing,
Tan Arlene,
Smith Douglas,
Clough Rich
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a598-d
Subject(s) - adult male , traumatic brain injury , medicine , neuroplasticity , psychology , neuroscience , psychiatry
Estrogenic (±)‐Z‐bis‐dehydrodoisynolic acid (Z‐BDA) facilitates functional recovery following fluid percussion injury (FPI) in adult male rats. Cortical Contusion Injury (CCI) also produces deficits in motor performance, reference memory, and alters neuroplasticity. The present study investigated the efficacy of Z‐BDA in facilitating recovery of function following CCI in young (post pubertal) rats and analyzed the neuropathological progression of CCI in relation to Z‐BDA and functional recovery. Young adult male rats were subjected to sham surgery or CCI followed by either (±), (−), (+)‐Z‐BDA or vehicle (0.3 μg/g BW, sc) at 2, 24, and 48 h. Behavioral testing lasted sixteen days after injury, and autopsies were performed on day seventeen. After brain sectioning, Fluoro‐Jade, GFAP and formal thionin staining was performed for histological analysis. Only one behavioral test (staircase reaching) showed significant differences between Z‐BDA and vehicle treated groups. In connection with these results, cortical loss was not significantly different between groups and only the (+)‐Z‐BDA group showed differences from vehicle in GFAP labeling. These results suggest that Z‐BDA is not effective in facilitating functional recovery after CCI in young rats nor does it have any apparent protective effect on CCI neuropathology. Support: NIH 5 R01 NS04155 and SIUSOM CRC.