Premium
Role of IL‐6 in DOCA salt hypertension
Author(s) -
Sturgis LaShon,
Boesen Erika,
Lane Katherine,
Brands Michael W
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a590
Subject(s) - aldosterone , endocrinology , medicine , blood pressure , angiotensin ii , renin–angiotensin system , chemistry
Ang II is known to stimulate IL‐6 release, and a study from our laboratory by Lee et al., that infused Ang II chronically (14days) in wild type (WT) and IL‐6 knockout (KO) mice, showed that the KO mice had an attenuated hypertensive response to Ang II. That suggested that IL‐6 mediates part of Ang II's hypertensive actions. However, Ang II also simulates aldosterone, which has its own hypertensive actions. This study aimed to determine whether the effect of IL‐6 in Ang II hypertension also might be due to IL‐6 mediating part of aldosterone's blood pressure actions. Mice were divided randomly into 4 groups: DOCA WT, DOCA IL‐6 KO, SHAM WT, and SHAM IL‐6 KO, and were implanted with blood pressure biotelemetry devices, uninephrectomized and allowed to recover for 5–7 days. After the baseline period (5 days) the DOCA animals had a DOCA pellet (1g/kg) implanted subcutaneously, and all animals were given a solution of 1% NaCl and 0.2% KCl to drink for a 14‐day experimental period. DOCA‐salt increased mean arterial pressure similarly by ~30 mmHg in both the WT and KO groups. However, DOCA did not increase plasma IL‐6 in WT mice, nor did it increase IL‐6 bioactivity using a B9 cell bioassay. Ang II induced hypertension is characterized by increased Ang II, aldosterone, and IL‐6, and these results suggest that the role of IL‐6 in mediating Ang II hypertension may be independent of interaction with aldosterone.