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Plasma Carotenoid Analysis in Colon Cancer Survivors and the General Population
Author(s) -
Paxton Amy,
Switzer Boyd R,
Carr Carol C,
Campbell Marci K
Publication year - 2007
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.21.5.a59-a
Subject(s) - quartile , medicine , odds ratio , colorectal cancer , logistic regression , population , carotenoid , odds , cancer , case control study , gastroenterology , confidence interval , biology , food science , environmental health
Understanding dietary patterns among cancer survivors can facilitate healthy behavior changes. Fruit and vegetable (F&V) intake is a key component of a healthy diet and may influence disease risk. Carotenoids, found abundantly in colorful F&V, are associated with lower risks of colorectal cancer (CRC). This study examined plasma carotenoid levels (CAROT) in CRC survivors (n=91) compared to controls (n=162) in NC STRIDES, a population‐based randomized study. A significant correlation (0.30, p<0.05) was found between CAROT levels and F&V intake, measured by a 35‐item validated FFQ. Self‐reported F&V intake did not differ between survivors and controls. CAROT (μg/ml) was categorized into quartiles: Quartile 1 ≤ 0.50; Quartile 2 < 0.50 & ≤ 0.70; Quartile 3< 0.70 & ≤ 0.95; Quartile 4 > 0.95. Multivariate logistic regression analysis assessed the prevalence odds of being a CRC survivor and having low CAROT, controlling for sex and age. Increasing, non‐significant odds ratios of low CAROT were associated with CRC survivorship. Prevalence ORs across quartiles of CAROT were 0.85 (0.39, 1.84), 0.60 (0.27, 1.32), 0.51 (0.22, 1.16); comparison group = Quartile 1. Thus, survivors were half as likely as controls to have plasma carotenoid levels in the highest quartile. This study provides evidence that CRC survivors have lower plasma carotenoids compared to the general population, possibly for reasons other than low F&V intake.